![](https://static.wixstatic.com/media/11062b_dadf974a47664e5cb42f939b7f17bec8f000.jpg/v1/fill/w_147,h_83,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/11062b_dadf974a47664e5cb42f939b7f17bec8f000.jpg)
![P29 White Logo.png](https://static.wixstatic.com/media/3923bd_16b0d2aa5e63420e8fc8c9fad7122f0c~mv2.png/v1/fill/w_600,h_183,al_c,q_85,enc_auto/3923bd_16b0d2aa5e63420e8fc8c9fad7122f0c~mv2.png)
Project-29 is advancing cancer screening, diagnostics and therapeutic monitoring – in humans and companion animals.
Cancer is
Transformative
![P29 White Logo.png](https://static.wixstatic.com/media/3923bd_16b0d2aa5e63420e8fc8c9fad7122f0c~mv2.png/v1/fill/w_60,h_18,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/3923bd_16b0d2aa5e63420e8fc8c9fad7122f0c~mv2.png)
Aims to define
​
What the cancer
IS
DOING
Cellular changes in Metabolism,
Proliferation, and Inflammation define key activities in cancer.
Thymidine Kinase Type 1
C-Reactive Protein
Isotopic Copper
Ratio
Thymidine Kinase Type 1
![P29 Diagram_white.png](https://static.wixstatic.com/media/3923bd_c8c194a56ab84dc18f059283905970b3~mv2.png/v1/fill/w_72,h_66,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/P29%20Diagram_white.png)
Metabolism
The deregulation of cellular energetics is a biochemical fingerprint of cancer.
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Cancer changes how energy is produced, typically from OXPHOS to aerobic glycolysis (Warburg effect). However, cancer is a heterogenous disease and each cancer may behave differently or even switch as demands dictate.
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Copper is essential for energy production and changing states may alter the stable, non-radioactive, isotopes 65Cu 63Cu. The ratio of these two isotopes δ(65)Cu provide insight into metabolic processes.
![Warburg Effect_with logo.jpg](https://static.wixstatic.com/media/3923bd_13424b478c8345f28a01a9425df26861~mv2.jpg/v1/fill/w_121,h_135,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Warburg%20Effect_with%20logo.jpg)
Proliferation
Unchecked proliferation is a
hallmark of cancer.
​
Cell division is dysregulated. A proven marker of dysregulated proliferation is thymidine kinase, type 1 (TK1) that makes the nucleotide thymine via the “salvage pathway”.
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TK1 is upregulated in proportion to rate of growth, overall tumor burden, and tumor grade.
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High grade metastatic cancers create high levels of TK1, especially lymphoma.
![Cancer Mechanism Diagram with logo.png](https://static.wixstatic.com/media/3923bd_6a8565eb5e744ab3a32aa9a469c8e926~mv2.png/v1/fill/w_80,h_48,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/Cancer%20Mechanism%20Diagram%20with%20logo.png)
![Blood Test](https://static.wixstatic.com/media/a5b6e8edfb63432792f48f95895df268.jpg/v1/fill/w_147,h_98,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/a5b6e8edfb63432792f48f95895df268.jpg)
A Novel Blood Test
New Multi-Biomarker Blood Panel for Cancer Activity.
The power of multi-biomarker panels is well proven.
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Independent metrics of a disease, when combined, help to improve sensitivity and specificity.
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Combining the power of three unique features of cancer activity, allows for a powerful diagnostic panel AND new metrics for therapeutic monitoring.
![Multibiomarker Panel Venn.png](https://static.wixstatic.com/media/3923bd_23a9d2db8a7648eeb2de0f2e30396cc2~mv2.png/v1/fill/w_73,h_44,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/Multibiomarker%20Panel%20Venn.png)
![Project 29 alpha bkgnd.png](https://static.wixstatic.com/media/3923bd_ef2fefe389ca4f70966049c8829e719e~mv2.png/v1/fill/w_114,h_32,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/Project%2029%20alpha%20bkgnd.png)
Current Investigators
Kim Selting
DVM, MS, DACVIM (oncology)
​
Associate Professor
Veterinary Clinical Medicine
University of Illinois
​
Kendra Pope
DVM, DACVIM (oncology), CVA, CVCH, CVFT, CVTP
​
Prism Integrative Veterinary Health
Projects of
Interest
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Validation in a wide range of tumor types
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Biomarker-driven drug selection
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Monitor disease remission & recurrence
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Applications for early detection/intervention with diet & lifestyle changes